The lives of the support crew serving on one of Starfleet's least important ships, the U.S.S. Cerritos, in 2380. Ensigns Mariner, Boimler, Rutherford and Tendi have to keep up with their duties and their social lives, often while the ship is being rocked by a multitude of sci-fi anomalies.

Craig of the Creek follows a young boy, Craig, and his two friends, Kelsey and JP, as they go on adventures within a world of untamed, kid-dominated wilderness in the creek.